A former client used some sort of Mac antivirus software on an older iMac, and it made several things very hard to use. I've been using one or more Mac systems since 2005, and have never used anti-virus software. Whether you should use any Mac antivirus software is a very interesting question. Mac antivirus software FAQ: What Mac antivirus software should I use? (Also written as, 'Do I need Mac anti-virus software?' or 'Should I use any Mac antivirus software at all?')